InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Degs2

Summary

InnateDB Protein

IDBP-170857.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Degs2

Protein Name

degenerative spermatocyte homolog 2 (Drosophila), lipid desaturase

Synonyms

2210008A03Rik; AI852933; DES2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000021691

InnateDB Gene

IDBG-170855 (Degs2)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase. {ECO:0000269PubMed:11937514, ECO:0000269PubMed:14731113, ECO:0000269PubMed:16571104}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:16571104, ECO:0000305}; Multi-pass membrane protein {ECO:0000269PubMed:16571104, ECO:0000305}.

Disease Associations

Tissue Specificity

Highly expressed in intestinal crypt cells and adjacent epithelial cells (at protein level). {ECO:0000269PubMed:14731113}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000170	sphingosine hydroxylase activity
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0042284	sphingolipid delta-4 desaturase activity

Biological Process

GO:0006629	lipid metabolic process
GO:0006667	sphinganine metabolic process
GO:0030148	sphingolipid biosynthetic process
GO:0046513	ceramide biosynthetic process
GO:0055114	oxidation-reduction process