Version 5.4
| Mus musculus Protein: Trmu | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Protein | IDBP-170917.6 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | Trmu | ||||||||||||||
| Protein Name | tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase | ||||||||||||||
| Synonyms | 1110005N20Rik; 1600025P05Rik; AI314320; Trmt1; | ||||||||||||||
| Species | Mus musculus | ||||||||||||||
| Ensembl Protein | ENSMUSP00000023019 | ||||||||||||||
| InnateDB Gene | IDBG-170915 (Trmu) | ||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||
| Function | Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2- thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base (By similarity). {ECO:0000250}. | ||||||||||||||
| Subcellular Localization | Mitochondrion {ECO:0000269PubMed:14746906}. | ||||||||||||||
| Disease Associations | |||||||||||||||
| Tissue Specificity | Widely expressed but most abundant in tissues with high metabolic rate including heart, liver and brain. Expression is low in spleen, testis, lung and skeletal muscle. Also expressed in inner ear. {ECO:0000269PubMed:14746906}. | ||||||||||||||
| Comments | |||||||||||||||
| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||
| PDB ID | MGI:1919276 | ||||||||||||||
| InterPro |
IPR004506
tRNA-specific 2-thiouridylase IPR020536 Thil, C-terminal domain IPR022310 NAD/GMP synthase |
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| PFAM |
PF03054
PF02568 PF02540 |
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| PRINTS | |||||||||||||||
| PIRSF | |||||||||||||||
| SMART | |||||||||||||||
| TIGRFAMs | |||||||||||||||
| Post-translational Modifications | |||||||||||||||
| Modification | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | Q9DAT5 | ||||||||||||||
| PhosphoSite | PhosphoSite- | ||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | 72026 | ||||||||||||||
| UniGene | |||||||||||||||
| RefSeq | NP_082339 | ||||||||||||||
| MGI ID | |||||||||||||||
| MGI Symbol | Trmu | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | CCDS27726 | ||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| EMBL | AK005541 AK043532 AK044059 AY349617 BC061026 | ||||||||||||||
| GenPept | AAH61026 AAQ55218 BAB24110 BAC31570 BAC31758 | ||||||||||||||