InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Palm

Summary

InnateDB Protein

IDBP-170968.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Palm

Protein Name

paralemmin

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040596

InnateDB Gene

IDBG-170966 (Palm)

Protein Structure

UniProt Annotation

Function

Involved in plasma membrane dynamics and cell process formation. Isoform 1 and isoform 2 are necessary for axonal and dendritic filopodia induction, for dendritic spine maturation and synapse formation in a palmitoylation-dependent manner. {ECO:0000269PubMed:18287537}.

Subcellular Localization

Cell membrane; Lipid-anchor; Cytoplasmic side. Cell projection, filopodium membrane; Lipid-anchor. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expression is highest in brain, intermediate in adrenal gland and kidney, and much lower or undetectable in other tissues. Isoform 1 is the predominant isoform in most tissues except brain and kidney where isoform 2 predominates. {ECO:0000269PubMed:9813098}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0031750	D3 dopamine receptor binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007194	negative regulation of adenylate cyclase activity
GO:0008104	protein localization
GO:0008360	regulation of cell shape
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0051491	positive regulation of filopodium assembly
GO:0060074	synapse maturation
GO:0060160	negative regulation of dopamine receptor signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0071257	cellular response to electrical stimulus
GO:0072661	protein targeting to plasma membrane

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016323	basolateral plasma membrane
GO:0016327	apicolateral plasma membrane
GO:0030175	filopodium
GO:0030424	axon
GO:0031527	filopodium membrane
GO:0032590	dendrite membrane
GO:0032591	dendritic spine membrane
GO:0044309	neuron spine