InnateDB Protein
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IDBP-170990.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cenpi
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Protein Name
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centromere protein I
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Synonyms
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AI504163; Fshprh1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000098809
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InnateDB Gene
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IDBG-170988 (Cenpi)
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Protein Structure
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Function |
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
10 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2147897
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InterPro |
IPR012485
Centromere protein I
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PFAM |
PF07778
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8K1K4
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PhosphoSite |
PhosphoSite-Q8K1K4
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TrEMBL |
B1AV88
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UniProt Splice Variant |
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Entrez Gene |
102920
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UniGene |
Mm.34903
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RefSeq |
XP_006528539
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MGI ID |
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MGI Symbol |
Cenpi
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OMIM |
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CCDS |
CCDS30393
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HPRD |
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IMGT |
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EMBL |
AK043344
AL672215
BC030328
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GenPept |
AAH30328
BAC31525
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