Version 5.4
Mus musculus Protein: Cenpi
Summary
InnateDB Protein IDBP-170992.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cenpi
Protein Name centromere protein I
Synonyms AI504163; Fshprh1;
Species Mus musculus
Ensembl Protein ENSMUSP00000079851
InnateDB Gene IDBG-170988 (Cenpi)
Protein Structure
UniProt Annotation
Function Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
GO:0034508 centromere complex assembly
Cellular Component
GO:0000776 kinetochore
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:2147897
InterPro IPR012485 Centromere protein I
PFAM PF07778
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K1K4
PhosphoSite PhosphoSite-Q8K1K4
TrEMBL B1AV88
UniProt Splice Variant
Entrez Gene 102920
UniGene Mm.34903
RefSeq NP_666036
MGI ID
MGI Symbol Cenpi
OMIM
CCDS CCDS30393
HPRD
IMGT
EMBL AK043344 AL672215 BC030328
GenPept AAH30328 BAC31525

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca