InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxw4

Summary

InnateDB Protein

IDBP-171001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxw4

Protein Name

F-box and WD-40 domain protein 4

Synonyms

Dac; dactylin; dactylyn; Fbw4; SHFM3; SHSF3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036505

InnateDB Gene

IDBG-170999 (Fbxw4)

Protein Structure

UniProt Annotation

Function

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0002053	positive regulation of mesenchymal cell proliferation
GO:0016055	Wnt signaling pathway
GO:0042733	embryonic digit morphogenesis
GO:0051216	cartilage development
GO:0060173	limb development