InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sacs

Summary

InnateDB Protein

IDBP-171015.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sacs

Protein Name

sacsin

Synonyms

A230052M14; DNAJC29; E130115J16Rik; mKIAA0730;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086816

InnateDB Gene

IDBG-171013 (Sacs)

Protein Structure

UniProt Annotation

Function

Co-chaperone which acts as a regulator of the Hsp70 chaperone machinery and may be involved in the processing of other ataxia-linked proteins. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Predominantly cytoplasmic, a small portion is present in the nucleus and also shows a partial mitochondrial overlap with the mitochondrial marker Hsp60. {ECO:0000250}.

Disease Associations

Tissue Specificity

Brain (at protein level). {ECO:0000269PubMed:19208651}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005524	ATP binding
GO:0030544	Hsp70 protein binding
GO:0050750	low-density lipoprotein particle receptor binding
GO:0051087	chaperone binding
GO:0070628	proteasome binding