Version 5.4
| Mus musculus Protein: Zfyve20 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Summary | |||||||||
| InnateDB Protein | IDBP-171027.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | Zfyve20 | ||||||||
| Protein Name | zinc finger, FYVE domain containing 20 | ||||||||
| Synonyms | 5330426D11Rik; | ||||||||
| Species | Mus musculus | ||||||||
| Ensembl Protein | ENSMUSP00000014694 | ||||||||
| InnateDB Gene | IDBG-171025 (Zfyve20) | ||||||||
| Protein Structure |
|
||||||||
| UniProt Annotation | |||||||||
| Function | Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3) (By similarity). {ECO:0000250}. | ||||||||
| Subcellular Localization | Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | |||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
|
||||||||
| Gene Ontology | |||||||||
Molecular Function |
|
||||||||
| Biological Process |
|
||||||||
| Cellular Component |
|
||||||||
| Protein Structure and Domains | |||||||||
| PDB ID | MGI:1925537 | ||||||||
| InterPro |
IPR000306
FYVE zinc finger IPR011011 Zinc finger, FYVE/PHD-type IPR017455 Zinc finger, FYVE-related IPR021565 FYVE-finger-containing Rab5 effector protein rabenosyn-5 |
||||||||
| PFAM |
PF01363
PF11464 |
||||||||
| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00064
|
||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q80Y56 | ||||||||
| PhosphoSite | PhosphoSite-Q80Y56 | ||||||||
| TrEMBL | D3Z0E7 | ||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 78287 | ||||||||
| UniGene | Mm.290734 | ||||||||
| RefSeq | NP_084357 | ||||||||
| MGI ID | |||||||||
| MGI Symbol | Zfyve20 | ||||||||
| OMIM | |||||||||
| CCDS | CCDS20374 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC164642 AK019909 BC031135 BC049106 | ||||||||
| GenPept | AAH31135 AAH49106 BAB31910 | ||||||||