Version 5.4
Mus musculus Protein: Fmnl2
Summary
InnateDB Protein IDBP-171092.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fmnl2
Protein Name formin-like 2
Synonyms 5430425K04Rik; Man;
Species Mus musculus
Ensembl Protein ENSMUSP00000088472
InnateDB Gene IDBG-171086 (Fmnl2)
Protein Structure
UniProt Annotation
Function Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the cortical actin filament dynamics (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0017048 Rho GTPase binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0016043 cellular component organization
GO:0022604 regulation of cell morphogenesis
GO:0030036 actin cytoskeleton organization
GO:0030866 cortical actin cytoskeleton organization
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1918659
InterPro IPR010472 Formin, FH3 domain
IPR010473 Formin, GTPase-binding domain
IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF06367
PF06371
PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt A2APV2
PhosphoSite PhosphoSite-A2APV2
TrEMBL Q6P247
UniProt Splice Variant
Entrez Gene 71409
UniGene Mm.475814
RefSeq XP_006498393
MGI ID
MGI Symbol Fmnl2
OMIM
CCDS
HPRD
IMGT
EMBL AF513716 AK173293 AL844510 AL844859 AL845170 BC048004 BC064731
GenPept AAH48004 AAH64731 AAP87551 BAD32571 CAM19034 CAM19613 CAM19616 CAM25963

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca