InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Atg10

Summary

InnateDB Protein

IDBP-171135.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Atg10

Protein Name

autophagy-related 10 (yeast)

Synonyms

5330424L23Rik; 5430428K15Rik; Agp10; AI852123; APG10; Apg10l; Apg10p; Atg10l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022119

InnateDB Gene

IDBG-171133 (Atg10)

Protein Structure

UniProt Annotation

Function

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3. Plays a role in adenovirus-mediated cell lysis. {ECO:0000269PubMed:12890687, ECO:0000269PubMed:20723759, ECO:0000269PubMed:21367888}.

Subcellular Localization

Cytoplasm {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019777	Atg12 ligase activity

Biological Process

GO:0006497	protein lipidation
GO:0006914	autophagy
GO:0015031	protein transport
GO:0031401	positive regulation of protein modification process
GO:0032446	protein modification by small protein conjugation
GO:0034263	autophagy in response to ER overload