Version 5.4
Mus musculus Protein: Psmd4
Summary
InnateDB Protein IDBP-171252.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Psmd4
Protein Name proteasome (prosome, macropain) 26S subunit, non-ATPase, 4
Synonyms Af1; angiocidin; Mcb1;
Species Mus musculus
Ensembl Protein ENSMUSP00000071589
InnateDB Gene IDBG-171250 (Psmd4)
Protein Structure
UniProt Annotation
Function Binds and presumably selects ubiquitin-conjugates for destruction.
Subcellular Localization
Disease Associations
Tissue Specificity Isoform Rpn10A is ubiquitous whereas isoform Rpn10E is mostly expressed in the embryonic brain.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 125 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 125 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0022624 proteasome accessory complex
Protein Structure and Domains
PDB ID MGI:1201670
InterPro IPR002035 von Willebrand factor, type A
IPR003903 Ubiquitin interacting motif
IPR007198 Ssl1-like
PFAM PF00092
PF02809
PF04056
PRINTS
PIRSF
SMART SM00327
SM00726
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35226
PhosphoSite PhosphoSite-O35226
TrEMBL Q3ULG4
UniProt Splice Variant
Entrez Gene 19185
UniGene Mm.466820
RefSeq NP_001268946
MGI ID
MGI Symbol Psmd4
OMIM
CCDS CCDS71287
HPRD
IMGT
EMBL AB029090 AB029142 AB029143 AB029144 AB029145 AB029146 AF013099 AF175574 AK145524 BC009005
GenPept AAC53547 AAG09199 AAH09005 BAA97572 BAA97573 BAA97574 BAA97575 BAA97576 BAA97577 BAE26484

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca