InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf7l

Summary

InnateDB Protein

IDBP-171283.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf7l

Protein Name

TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor

Synonyms

4933438I11Rik; 50kDa; Taf2q;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000009740

InnateDB Gene

IDBG-171281 (Taf7l)

Protein Structure

UniProt Annotation

Function

Probably functions as a spermatogensis-specific component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. May play a role in spermatogenesis. {ECO:0000269PubMed:12665565}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Cytoplasmic in spermatogonia and early spermatocytes (preleptotene, leptotene, and zygotene); translocates into the nuclei of pachytene spermatocytes and round spermatids.

Disease Associations

Tissue Specificity

Testis-specific (at protein level). Expressed during spermatogenesis from spermatogonia stage up to the stage of round spermatids. {ECO:0000269PubMed:11279525, ECO:0000269PubMed:17242199}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006367	transcription initiation from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0007286	spermatid development
GO:0030317	sperm motility