InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spata18

Summary

InnateDB Protein

IDBP-171300.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spata18

Protein Name

spermatogenesis associated 18

Synonyms

1700067I02Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064308

InnateDB Gene

IDBG-171296 (Spata18)

Protein Structure

UniProt Annotation

Function

Key regulator of mitochondrial quality that mediates the repairing or degradation of unhealthy mitochondria in response to mitochondrial damage. Mediator of mitochondrial protein catabolic process (also named MALM) by mediating the degradation of damaged proteins inside mitochondria by promoting the accumulation in the mitochondrial matrix of hydrolases that are characteristic of the lysosomal lumen. Also involved in mitochondrion degradation of damaged mitochondria by promoting the formation of vacuole-like structures (named MIV), which engulf and degrade unhealthy mitochondria by accumulating lysosomes. May have a role in spermatogenesis, especially in cell differentiation from late elongate spermatids to mature spermatozoa (By similarity). The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Localizes to the cytoplasm under normal conditions. Relocalizes to mitochondrion outer membrane following cellular stress (By similarity). Colocalizes with BNIP3 and BNIP3L at the mitochondrion outer membrane (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

In testis, expressed primarily in spermatids. {ECO:0000269PubMed:21300779}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0035694	mitochondrial protein catabolic process
GO:0035695	mitochondrion degradation by induced vacuole formation