InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elane

Summary

InnateDB Protein

IDBP-171369.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elane

Protein Name

elastase, neutrophil expressed

Synonyms

Ela2; F430011M15Rik; NE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000038925

InnateDB Gene

IDBG-171367 (Elane)

Protein Structure

UniProt Annotation

Function

Medullasin modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	39 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001106	RNA polymerase II transcription corepressor activity
GO:0002020	protease binding
GO:0003824	catalytic activity
GO:0004175	endopeptidase activity
GO:0004252	serine-type endopeptidase activity
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0008233	peptidase activity
GO:0019955	cytokine binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001878	response to yeast
GO:0002438	acute inflammatory response to antigenic stimulus
GO:0006508	proteolysis
GO:0006909	phagocytosis
GO:0009411	response to UV
GO:0032496	response to lipopolysaccharide
GO:0042742	defense response to bacterium
GO:0044130	negative regulation of growth of symbiont in host
GO:0045079	negative regulation of chemokine biosynthetic process
GO:0045415	negative regulation of interleukin-8 biosynthetic process
GO:0045416	positive regulation of interleukin-8 biosynthetic process
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050778	positive regulation of immune response
GO:0050832	defense response to fungus
GO:0050900	leukocyte migration
GO:0070947	neutrophil mediated killing of fungus

Cellular Component

GO:0005737	cytoplasm
GO:0009986	cell surface
GO:0017053	transcriptional repressor complex
GO:0030141	secretory granule
GO:0070062	extracellular vesicular exosome