Version 5.4
Mus musculus Protein: Rprm
Summary
InnateDB Protein IDBP-171423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rprm
Protein Name reprimo, TP53 dependent G2 arrest mediator candidate
Synonyms 2410012A13Rik; Reprimo;
Species Mus musculus
Ensembl Protein ENSMUSP00000097667
InnateDB Gene IDBG-171421 (Rprm)
Protein Structure
UniProt Annotation
Function May be involved in the regulation of p53-dependent G2 arrest of the cell cycle. Seems to induce cell cycle arrest by inhibiting CDK1 activity and nuclear translocation of the CDC2 cyclin B1 complex. {ECO:0000269PubMed:10930422}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:10930422}. Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007050 cell cycle arrest
GO:0007346 regulation of mitotic cell cycle
Cellular Component
GO:0005737 cytoplasm
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1915124
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JJ72
PhosphoSite PhosphoSite-Q9JJ72
TrEMBL
UniProt Splice Variant
Entrez Gene 67874
UniGene Mm.27086
RefSeq NP_075885
MGI ID
MGI Symbol Rprm
OMIM
CCDS CCDS16040
HPRD
IMGT
EMBL AB043586 AK010465 AK014769 AL844850 BC030065
GenPept AAH30065 BAB01514 BAB26960 BAB29541 CAM18780

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca