Version 5.4
Mus musculus Protein: Tmod4
Summary
InnateDB Protein IDBP-171459.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmod4
Protein Name tropomodulin 4
Synonyms MTMOD; Sk-Tmod;
Species Mus musculus
Ensembl Protein ENSMUSP00000005769
InnateDB Gene IDBG-171457 (Tmod4)
Protein Structure
UniProt Annotation
Function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005523 tropomyosin binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005856 cytoskeleton
GO:0005865 striated muscle thin filament
Protein Structure and Domains
PDB ID MGI:1355285
InterPro IPR004934 Tropomodulin
PFAM PF03250
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9JLH8
PhosphoSite PhosphoSite-
TrEMBL Q3UN19
UniProt Splice Variant
Entrez Gene 50874
UniGene Mm.71935
RefSeq NP_057921
MGI ID
MGI Symbol Tmod4
OMIM
CCDS CCDS17601
HPRD
IMGT
EMBL AC131769 AF177174 AK144408 AK144535 BC068020 CH466620
GenPept AAF31673 AAH68020 BAE25875 BAE25929 EDL38774

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca