Version 5.4
Mus musculus Protein: Aff4
Summary
InnateDB Protein IDBP-171482.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Aff4
Protein Name AF4/FMR2 family, member 4
Synonyms AF5Q31; Alf4; Laf4l; MCEF;
Species Mus musculus
Ensembl Protein ENSMUSP00000051479
InnateDB Gene IDBG-171480 (Aff4)
Protein Structure
UniProt Annotation
Function Key component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins (ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:22195968}. Note=Associates to transcriptionally active chromatin but not at snRNA genes.
Disease Associations
Tissue Specificity Highly expressed in testis by Sertoli cells, and at low levels in other tissues. {ECO:0000269PubMed:16024815}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 4 [view]
Protein-DNA 5 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 34 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007286 spermatid development
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID MGI:2136171
InterPro IPR007797 Transcription factor AF4/FMR2
PFAM PF05110
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESC8
PhosphoSite PhosphoSite-Q9ESC8
TrEMBL B7ZC42
UniProt Splice Variant
Entrez Gene 93736
UniGene Mm.395281
RefSeq NP_291043
MGI ID
MGI Symbol Aff4
OMIM
CCDS CCDS24676
HPRD
IMGT
EMBL AF190449 AK033163 AK053034 AK054401 AL592489 BC138999
GenPept AAG17126 AAI39000 BAC28178 BAC35244 BAC35763

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca