InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Kiss1r

Summary

InnateDB Protein

IDBP-171621.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kiss1r

Protein Name

KISS1 receptor

Synonyms

Gpr54; KiSS-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040516

InnateDB Gene

IDBG-171619 (Kiss1r)

Protein Structure

UniProt Annotation

Function

Receptor for metastin (kisspeptin-52 or kp-52), a C- terminally amidated peptide of KiSS1. KiSS1 is a metastasis suppressor protein. Activation of the receptor inhibits cell proliferation and cell migration, key characteristics of tumor metastasis. The receptor is essential for normal gonadotropin- released hormone physiology and for puberty. The hypothalamic KiSS1/KISS1R system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood. Analysis of the transduction pathways activated by the receptor identifies coupling to phospholipase C and intracellular calcium release through pertussis toxin-insensitive G(q) proteins.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Highest level in the heart and 15- and 17-day embryos. Low level in other tissues. Colocalized with gonadotropin-releasing hormone (GnRH) neurons in the hypothalamus. {ECO:0000269PubMed:11414709, ECO:0000269PubMed:12359743, ECO:0000269PubMed:15665093}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005515	protein binding
GO:0008188	neuropeptide receptor activity
GO:0008528	G-protein coupled peptide receptor activity
GO:0042923	neuropeptide binding

Biological Process

GO:0000186	activation of MAPKK activity
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007218	neuropeptide signaling pathway
GO:0008285	negative regulation of cell proliferation
GO:0019722	calcium-mediated signaling
GO:0046887	positive regulation of hormone secretion
GO:0050482	arachidonic acid secretion
GO:0050806	positive regulation of synaptic transmission
GO:0051496	positive regulation of stress fiber assembly

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:2148793

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000405 Galanin receptor family
IPR000611 Neuropeptide Y receptor family
IPR008103 KiSS-1 peptide receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00663
PR01012
PR01728

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q91V45