InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arid3a

Summary

InnateDB Protein

IDBP-171664.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arid3a

Protein Name

AT rich interactive domain 3A (BRIGHT-like)

Synonyms

Bright; Dri1; Dril1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019708

InnateDB Gene

IDBG-171662 (Arid3a)

Protein Structure

UniProt Annotation

Function

Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy- chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway. {ECO:0000269PubMed:11294836, ECO:0000269PubMed:17312145, ECO:0000269PubMed:8543152}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.

Disease Associations

Tissue Specificity

B-cell specific in the adult. Expressed in B- cell progenitors, down-regulated in the immature B-cell stage, and is up-regulated again at later stages of B-lymphocyte differentiation. {ECO:0000269PubMed:9590220}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	3 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter