InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrig1

Summary

InnateDB Protein

IDBP-171705.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrig1

Protein Name

leucine-rich repeats and immunoglobulin-like domains 1

Synonyms

D6Bwg0781e; Img; LIG-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032105

InnateDB Gene

IDBG-171701 (Lrig1)

Protein Structure

UniProt Annotation

Function

Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Predominantly expressed in the brain, restricted to a small subset of glial cells, such as Bergmann glial cells of the cerebellum and glial cells in the nerve fiber layer of the olfactory bulb. Expressed also in the skin. Low expression is detected in the thymus and heart. No expression in the kidney, liver, lung or small intestine. {ECO:0000269PubMed:12067728, ECO:0000269PubMed:8798419}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0007605	sensory perception of sound
GO:0032474	otolith morphogenesis
GO:0060384	innervation

Cellular Component

GO:0016021

integral component of membrane

Protein Structure and Domains

PDB ID

MGI:107935

InterPro

IPR000372 Leucine-rich repeat-containing N-terminal
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM