InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glis1

Summary

InnateDB Protein

IDBP-171732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glis1

Protein Name

GLIS family zinc finger 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000035650

InnateDB Gene

IDBG-171730 (Glis1)

Protein Structure

UniProt Annotation

Function

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. {ECO:0000269PubMed:12042312, ECO:0000269PubMed:12385751}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:12042312}.

Disease Associations

Tissue Specificity

In the adult, expressed highly in placenta and kidney and at lower levels in the testis, brain, colon, brown fat tissue and thymus. During embryo development, expressed in the frontal nasal region, branchial arches, somites, vibrissal and hair follicles, limb buds, craniofacial regions, ventral part of the tail, intervertebral disks, teeth, eyes and kidney. {ECO:0000269PubMed:12042312, ECO:0000269PubMed:12385751}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter