InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hamp2

Summary

InnateDB Protein

IDBP-171757.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hamp2

Protein Name

hepcidin antimicrobial peptide 2

Synonyms

1810073K19Rik; HEPC2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074240

InnateDB Gene

IDBG-171755 (Hamp2)

Protein Structure

UniProt Annotation

Function

Seems to act as a signaling molecule involved in the maintenance of iron homeostasis. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Highly expressed in the liver and to a much lesser extent in the heart. Also expressed in pancreas. {ECO:0000269PubMed:12729891}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity

Biological Process

GO:0006879	cellular iron ion homeostasis
GO:0031640	killing of cells of other organism
GO:0042742	defense response to bacterium
GO:0050832	defense response to fungus

Cellular Component

GO:0005576

extracellular region

Protein Structure and Domains

PDB ID

MGI:2153530

InterPro

IPR010500 Hepcidin

PFAM

PF06446

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q80T19

PhosphoSite

PhosphoSite-

TrEMBL

Q5M9M1

UniProt Splice Variant

Entrez Gene

66438

UniGene

RefSeq

NP_899080

MGI ID

MGI Symbol

Hamp2

OMIM

CCDS

CCDS39894

HPRD

IMGT

EMBL

AC149055 AK007975 AK008993 AY232841 BC086895

GenPept

AAH86895 AAO73588 BAC25194 BAC25234