InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grin3b

Summary

InnateDB Protein

IDBP-171797.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grin3b

Protein Name

glutamate receptor, ionotropic, NMDA3B

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048576

InnateDB Gene

IDBG-171795 (Grin3b)

Protein Structure

UniProt Annotation

Function

NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:14602821}; Multi-pass membrane protein {ECO:0000269PubMed:14602821}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000269PubMed:14602821}. Note=Requires the presence of GRIN1 to be targeted at the plasma membrane.

Disease Associations

Tissue Specificity

Expressed in the facial nucleus and the ambiguus nucleus of the brainstem, pons, medulla, spinal cord and cerebellum. {ECO:0000269PubMed:11717388, ECO:0000269PubMed:12008020, ECO:0000269PubMed:14602821}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004970	ionotropic glutamate receptor activity
GO:0004972	N-methyl-D-aspartate selective glutamate receptor activity
GO:0005215	transporter activity
GO:0005234	extracellular-glutamate-gated ion channel activity
GO:0005262	calcium channel activity

Biological Process

GO:0006810	transport
GO:0034220	ion transmembrane transport
GO:0035235	ionotropic glutamate receptor signaling pathway
GO:0035249	synaptic transmission, glutamatergic
GO:0051205	protein insertion into membrane
GO:0051924	regulation of calcium ion transport
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0016020	membrane
GO:0017146	N-methyl-D-aspartate selective glutamate receptor complex
GO:0030054	cell junction
GO:0030425	dendrite
GO:0043025	neuronal cell body
GO:0045211	postsynaptic membrane

Protein Structure and Domains

PDB ID

MGI:2150393

InterPro

IPR001320 Ionotropic glutamate receptor
IPR001508 NMDA receptor
IPR001638 Extracellular solute-binding protein, family 3
IPR019594 Glutamate receptor, L-glutamate/glycine-binding
IPR028082 Periplasmic binding protein-like I

PFAM

PF00060
PF00497
PF10613

PRINTS

PR00177

PIRSF

SMART

SM00079
SM00062
SM00918

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt