InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lsr

Summary

InnateDB Protein

IDBP-171879.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lsr

Protein Name

lipolysis stimulated lipoprotein receptor

Synonyms

ILDR3; Lisch7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000001279

InnateDB Gene

IDBG-171877 (Lsr)

Protein Structure

UniProt Annotation

Function

Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Specifically expressed in liver and to a lower extent in kidney (at protein level). Also detected in brain, testis, ovaries, adrenal gland, intestine, muscle, and lung. {ECO:0000269PubMed:15265030}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0030169	low-density lipoprotein particle binding
GO:0030228	lipoprotein particle receptor activity

Biological Process

GO:0001889	liver development
GO:0006898	receptor-mediated endocytosis
GO:0009790	embryo development
GO:0019216	regulation of lipid metabolic process
GO:0042953	lipoprotein transport

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0034361	very-low-density lipoprotein particle
GO:0034362	low-density lipoprotein particle
GO:0042627	chylomicron
GO:0070062	extracellular vesicular exosome