InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ermn

Summary

InnateDB Protein

IDBP-171896.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ermn

Protein Name

ermin, ERM-like protein

Synonyms

A330104H05Rik; AI854460; ermin; mKIAA1189;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088458

InnateDB Gene

IDBG-171894 (Ermn)

Protein Structure

UniProt Annotation

Function

Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:16421295}.

Disease Associations

Tissue Specificity

Brain and spinal cord. Exclusively expressed by the oligodendrocytes. Appears at a late stage during myelination, and in the mature nerves, it is localized to the outer cytoplasmic lip of the myelin sheath and the paranodal loops. {ECO:0000269PubMed:16421295}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0051015	actin filament binding

Biological Process

GO:0001763	morphogenesis of a branching structure
GO:0007015	actin filament organization
GO:0008360	regulation of cell shape
GO:0031344	regulation of cell projection organization

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005938	cell cortex
GO:0030175	filopodium
GO:0033269	internode region of axon
GO:0033270	paranode region of axon
GO:0043025	neuronal cell body
GO:0043209	myelin sheath
GO:0070062	extracellular vesicular exosome