InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Suclg2

Summary

InnateDB Protein

IDBP-171911.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Suclg2

Protein Name

succinate-Coenzyme A ligase, GDP-forming, beta subunit

Synonyms

AF171077; AW556404; D6Wsu120e; SCS-betaG;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078774

InnateDB Gene

IDBG-171909 (Suclg2)

Protein Structure

UniProt Annotation

Function

Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA. {ECO:0000250}.

Subcellular Localization

Mitochondrion.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004776	succinate-CoA ligase (GDP-forming) activity
GO:0004777	succinate-semialdehyde dehydrogenase (NAD+) activity
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0019003	GDP binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006099	tricarboxylic acid cycle
GO:0006104	succinyl-CoA metabolic process
GO:0006105	succinate metabolic process
GO:0008152	metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005886	plasma membrane
GO:0043234	protein complex
GO:0045244	succinate-CoA ligase complex (GDP-forming)

Protein Structure and Domains

PDB ID

MGI:1306824

InterPro

IPR005809 Succinyl-CoA synthetase, beta subunit
IPR005811 ATP-citrate lyase/succinyl-CoA ligase
IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
IPR016102 Succinyl-CoA synthetase-like

PFAM

PF00549
PF08442

PRINTS

PIRSF

PIRSF001554

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9Z2I8