InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdc42se1

Summary

InnateDB Protein

IDBP-172009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdc42se1

Protein Name

CDC42 small effector 1

Synonyms

1300002M12Rik; AW558204; Cdcse1; SCIP1; Spec1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000052986

InnateDB Gene

IDBG-172007 (Cdc42se1)

Protein Structure

UniProt Annotation

Function

Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0006909	phagocytosis
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0046329	negative regulation of JNK cascade