InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pbx2

Summary

InnateDB Protein

IDBP-172074.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pbx2

Protein Name

pre B-cell leukemia transcription factor 2

Synonyms

AU043397; G17;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040464

InnateDB Gene

IDBG-172072 (Pbx2)

Protein Structure

UniProt Annotation

Function

Transcriptional activator that binds the sequence 5'- ATCAATCAA-3'. Activates transcription of PF4 in complex with MEIS1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0009954	proximal/distal pattern formation
GO:0030326	embryonic limb morphogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter