InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rad50

Summary

InnateDB Protein

IDBP-172116.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rad50

Protein Name

RAD50 homolog (S. cerevisiae)

Synonyms

Mrell; Rad50l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020649

InnateDB Gene

IDBG-172112 (Rad50)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	5 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	58 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000014	single-stranded DNA endodeoxyribonuclease activity
GO:0003677	DNA binding
GO:0004003	ATP-dependent DNA helicase activity
GO:0004518	nuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008270	zinc ion binding
GO:0008408	3'-5' exonuclease activity
GO:0030674	protein binding, bridging

Biological Process

GO:0000019	regulation of mitotic recombination
GO:0000737	DNA catabolic process, endonucleolytic
GO:0006281	DNA repair
GO:0006302	double-strand break repair
GO:0006310	DNA recombination
GO:0006974	cellular response to DNA damage stimulus
GO:0007004	telomere maintenance via telomerase
GO:0031954	positive regulation of protein autophosphorylation
GO:0032508	DNA duplex unwinding
GO:0033674	positive regulation of kinase activity
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0000784	nuclear chromosome, telomeric region
GO:0005634	nucleus
GO:0016020	membrane
GO:0030870	Mre11 complex
GO:0035861	site of double-strand break
GO:0045120	pronucleus

Protein Structure and Domains

PDB ID

MGI:109292

InterPro

IPR004584 DNA repair protein Rad50, eukaryotes
IPR007517 Rad50 zinc hook
IPR009053 Prefoldin
IPR013134 Zinc hook, Rad50
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF04423

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-