Version 5.4
Mus musculus Protein: Tmf1
Summary
InnateDB Protein IDBP-172127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tmf1
Protein Name TATA element modulatory factor 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000093325
InnateDB Gene IDBG-172123 (Tmf1)
Protein Structure
UniProt Annotation
Function Potential coactivator of the androgen receptor. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER (By similarity). Mediates STAT3 degradation. {ECO:0000250, ECO:0000269PubMed:15467733}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Golgi apparatus membrane {ECO:0000250}. Note=Concentrated at the budding structures localized at the tips of cisternae. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0001675 acrosome assembly
GO:0001819 positive regulation of cytokine production
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007286 spermatid development
GO:0007289 spermatid nucleus differentiation
GO:0008584 male gonad development
GO:0010629 negative regulation of gene expression
GO:0030317 sperm motility
GO:0032275 luteinizing hormone secretion
GO:0033327 Leydig cell differentiation
GO:0042742 defense response to bacterium
GO:0043066 negative regulation of apoptotic process
GO:0061136 regulation of proteasomal protein catabolic process
GO:0071407 cellular response to organic cyclic compound
GO:2000845 positive regulation of testosterone secretion
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:2684999
InterPro IPR022091 TATA element modulatory factor 1 TATA binding
IPR022092 TATA element modulatory factor 1 DNA binding
PFAM PF12325
PF12329
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt B9EKI3
PhosphoSite PhosphoSite-NP_001074580
TrEMBL
UniProt Splice Variant
Entrez Gene 232286
UniGene Mm.489711
RefSeq NP_001074580
MGI ID
MGI Symbol Tmf1
OMIM
CCDS CCDS39575
HPRD
IMGT
EMBL AC155724 AK144729 AK144898 BC150931
GenPept AAI50932 BAE26035 BAE26120

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca