Mus musculus Protein: Tmprss15 | |||||||||||
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Summary | |||||||||||
InnateDB Protein | IDBP-172159.6 | ||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||
Gene Symbol | Tmprss15 | ||||||||||
Protein Name | transmembrane protease, serine 15 | ||||||||||
Synonyms | Entk; Prss7; | ||||||||||
Species | Mus musculus | ||||||||||
Ensembl Protein | ENSMUSP00000023566 | ||||||||||
InnateDB Gene | IDBG-172157 (Tmprss15) | ||||||||||
Protein Structure | |||||||||||
UniProt Annotation | |||||||||||
Function | Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases (By similarity). {ECO:0000250}. | ||||||||||
Subcellular Localization | Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. | ||||||||||
Disease Associations | |||||||||||
Tissue Specificity | |||||||||||
Comments | |||||||||||
Interactions | |||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||
PDB ID | MGI:1197523 | ||||||||||
InterPro |
IPR000082
SEA domain IPR000859 CUB domain IPR000998 MAM domain IPR001190 SRCR domain IPR001254 Peptidase S1 IPR001314 Peptidase S1A, chymotrypsin-type IPR002172 Low-density lipoprotein (LDL) receptor class A repeat IPR008985 Concanavalin A-like lectin/glucanases superfamily IPR009003 Trypsin-like cysteine/serine peptidase domain IPR011163 Peptidase S1A, enteropeptidase IPR015420 Peptidase S1A, nudel IPR017448 SRCR-like domain |
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PFAM |
PF01390
PF00431 PF00629 PF00530 PF00089 PF00057 PF09342 |
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PRINTS |
PR00020
PR00258 PR00722 PR00261 |
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PIRSF |
PIRSF001138
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SMART |
SM00200
SM00042 SM00137 SM00020 SM00192 SM00202 |
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TIGRFAMs | |||||||||||
Post-translational Modifications | |||||||||||
Modification | |||||||||||
Cross-References | |||||||||||
SwissProt | P97435 | ||||||||||
PhosphoSite | PhosphoSite- | ||||||||||
TrEMBL | Q8CAN9 | ||||||||||
UniProt Splice Variant | |||||||||||
Entrez Gene | 19146 | ||||||||||
UniGene | Mm.5184 | ||||||||||
RefSeq | NP_032967 | ||||||||||
MGI ID | |||||||||||
MGI Symbol | Tmprss15 | ||||||||||
OMIM | |||||||||||
CCDS | CCDS28280 | ||||||||||
HPRD | |||||||||||
IMGT | |||||||||||
EMBL | AK038356 BC117917 BC117918 U73378 | ||||||||||
GenPept | AAB37317 AAI17918 AAI17919 BAC29973 | ||||||||||