InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prune

Summary

InnateDB Protein

IDBP-172175.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prune

Protein Name

prune homolog (Drosophila)

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015855

InnateDB Gene

IDBG-172173 (Prune)

Protein Structure

UniProt Annotation

Function

Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell junction, focal adhesion {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0004427	inorganic diphosphatase activity
GO:0005515	protein binding
GO:0016462	pyrophosphatase activity
GO:0016787	hydrolase activity
GO:0030145	manganese ion binding