InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elovl3

Summary

InnateDB Protein

IDBP-172221.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elovl3

Protein Name

elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3

Synonyms

Cig30; CIN-2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000036357

InnateDB Gene

IDBG-172219 (Elovl3)

Protein Structure

UniProt Annotation

Function

Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs) of up to 24 carbon atoms. Participates in the formation of certain VLCFA and triglycerides in certain cells of the hair follicles and the sebaceous glands, required for skin barrier function. Critical enzyme for lipid accumulation and metabolic activity in brown adipocytes during the early phase of the tissue recruitment. Play a role in lipid storage and in resistance to diet-induced obesity. {ECO:0000269PubMed:10791983, ECO:0000269PubMed:14581464, ECO:0000269PubMed:16326704, ECO:0000269PubMed:20605947}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:10429212}; Multi-pass membrane protein {ECO:0000269PubMed:10429212}.

Disease Associations

Tissue Specificity

Expressed in brown adipose tissue and liver. In the skin, strong expressed in the cells of the inner layer of the outer root sheath of the hair follicles and in the sebocytes of the sebaceous glands. Hardly detectable in the epidermis and not at all in fibroblasts. {ECO:0000269PubMed:14581464, ECO:0000269PubMed:9395518}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0016740	transferase activity

Biological Process

GO:0019367	fatty acid elongation, saturated fatty acid
GO:0034625	fatty acid elongation, monounsaturated fatty acid
GO:0034626	fatty acid elongation, polyunsaturated fatty acid
GO:0042761	very long-chain fatty acid biosynthetic process