Version 5.4
Mus musculus Protein: Sgpp2
Summary
InnateDB Protein IDBP-172327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sgpp2
Protein Name sphingosine-1-phosphate phosphotase 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000036656
InnateDB Gene IDBG-172325 (Sgpp2)
Protein Structure
UniProt Annotation
Function Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0042392 sphingosine-1-phosphate phosphatase activity
Biological Process
GO:0006670 sphingosine metabolic process
GO:0016311 dephosphorylation
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:3589109
InterPro IPR000326 Phosphatidic acid phosphatase type 2/haloperoxidase
PFAM PF01569
PRINTS
PIRSF
SMART SM00014
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q810K3
PhosphoSite PhosphoSite-Q810K3
TrEMBL
UniProt Splice Variant
Entrez Gene 433323
UniGene Mm.276248
RefSeq NP_001004173
MGI ID
MGI Symbol Sgpp2
OMIM
CCDS CCDS15083
HPRD
IMGT
EMBL BC049995 BC147843 BC147850
GenPept AAH49995 AAI47844 AAI47851

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca