InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ptger1

Summary

InnateDB Protein

IDBP-172353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ptger1

Protein Name

prostaglandin E receptor 1 (subtype EP1)

Synonyms

42kDa; EP1; Ptgerep1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000019608

InnateDB Gene

IDBG-172351 (Ptger1)

Protein Structure

UniProt Annotation

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(q) proteins which activate a phosphatidylinositol-calcium second messenger system. May play a role as an important modulator of renal function. Implicated the smooth muscle contractile response to PGE2 in various tissues.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Abundant in kidney and in a lesser amount in lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004957	prostaglandin E receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0032496	response to lipopolysaccharide

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:97793

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000708 Prostanoid EP1 receptor
IPR001244 Prostaglandin DP receptor
IPR008365 Prostanoid receptor
IPR017452 GPCR, rhodopsin-like, 7TM

PFAM

PF00001

PRINTS

PR00237
PR00580
PR00428
PR01788

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P35375