Mus musculus Protein: Frmd4b
Summary
InnateDB Protein IDBP-172370.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Frmd4b
Protein Name FERM domain containing 4B
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000032146
InnateDB Gene IDBG-172368 (Frmd4b)
Protein Structure
UniProt Annotation
Function Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:11445584}.
Disease Associations
Tissue Specificity Isoform 1 is expressed in the brain. Isoform 2 is expressed in the lung (at protein level). {ECO:0000269PubMed:11445584}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0001726 ruffle
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Protein Structure and Domains
PDB ID MGI:2141794
InterPro IPR000299 FERM domain
IPR018979 FERM, N-terminal
IPR018980 FERM, C-terminal PH-like domain
IPR019748 FERM central domain
IPR019749 Band 4.1 domain
IPR019750 Band 4.1 family
IPR021774 Protein of unknown function DUF3338
IPR029071 Ubiquitin-related domain
PFAM PF09379
PF09380
PF00373
PF11819
PRINTS PR00935
PIRSF
SMART SM00295
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q920B0
PhosphoSite PhosphoSite-Q920B0
TrEMBL Q8C0E8
UniProt Splice Variant
Entrez Gene 232288
UniGene Mm.409301
RefSeq XP_006506069
MGI ID
MGI Symbol Frmd4b
OMIM
CCDS
HPRD
IMGT
EMBL AB042027 AF327856 AF327857 AK031491 AK132280 BC052390
GenPept AAH52390 AAL26916 AAL26917 BAB17031 BAC27423 BAE21079