InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scp2

Summary

InnateDB Protein

IDBP-172395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scp2

Protein Name

sterol carrier protein 2, liver

Synonyms

AA409774; AA409893; C76618; C79031; ns-LTP; NSL-TP; SCP-2; SCP-X; SCPX;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030340

InnateDB Gene

IDBG-172393 (Scp2)

Protein Structure

UniProt Annotation

Function

Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis.

Subcellular Localization

Cytoplasm. Note=Cytoplasmic in the liver and also associated with mitochondria especially in steroidogenic tissues.Isoform SCP2: Mitochondrion.Isoform SCPx: Peroxisome. Note=Interaction with PEX5 is essential for peroxisomal import. {ECO:0000250}.

Disease Associations

Tissue Specificity

Present at low levels in all tissues examined but expressed predominantly in the liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000062	fatty-acyl-CoA binding
GO:0003824	catalytic activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008526	phosphatidylinositol transporter activity
GO:0015485	cholesterol binding
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups
GO:0033814	propanoyl-CoA C-acyltransferase activity
GO:0036042	long-chain fatty acyl-CoA binding
GO:0050632	propionyl-CoA C2-trimethyltridecanoyltransferase activity
GO:0070538	oleic acid binding

Biological Process

GO:0006637	acyl-CoA metabolic process
GO:0006694	steroid biosynthetic process
GO:0006701	progesterone biosynthetic process
GO:0007031	peroxisome organization
GO:0008152	metabolic process
GO:0015914	phospholipid transport
GO:0032385	positive regulation of intracellular cholesterol transport
GO:0032959	inositol trisphosphate biosynthetic process
GO:0045940	positive regulation of steroid metabolic process
GO:0072659	protein localization to plasma membrane
GO:1901373	lipid hydroperoxide transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0016020	membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome