Version 5.4
Mus musculus Protein: Slc22a21
Summary
InnateDB Protein IDBP-172398.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Slc22a21
Protein Name solute carrier family 22 (organic cation transporter), member 21
Synonyms Octn3; Slc22a9;
Species Mus musculus
Ensembl Protein ENSMUSP00000075814
InnateDB Gene IDBG-172396 (Slc22a21)
Protein Structure
UniProt Annotation
Function Sodium-ion independent, medium affinity carnitine transporter. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 746. {ECO:0000269PubMed:11010964}.
Subcellular Localization Peroxisome membrane {ECO:0000269PubMed:11010964, ECO:0000269PubMed:12535646, ECO:0000269PubMed:16288981}; Multi-pass membrane protein {ECO:0000269PubMed:11010964, ECO:0000269PubMed:12535646, ECO:0000269PubMed:16288981}.
Disease Associations
Tissue Specificity Predominantly expressed in testis. {ECO:0000269PubMed:11010964}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0015075 ion transmembrane transporter activity
GO:0015226 carnitine transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0015879 carnitine transport
GO:0034220 ion transmembrane transport
GO:0055085 transmembrane transport
GO:1902603 carnitine transmembrane transport
Cellular Component
GO:0005777 peroxisome
GO:0016021 integral component of membrane
GO:0031231 intrinsic component of peroxisomal membrane
Protein Structure and Domains
PDB ID MGI:1929481
InterPro IPR004749 Organic cation transport protein
IPR005828 General substrate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain
PFAM PF00083
PF07690
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTN6
PhosphoSite PhosphoSite-Q9WTN6
TrEMBL A2RSK7
UniProt Splice Variant
Entrez Gene 56517
UniGene
RefSeq NP_062697
MGI ID
MGI Symbol Slc22a21
OMIM
CCDS CCDS24688
HPRD
IMGT
EMBL AB018436 AK133431 AK161508 AL596444 BC132147 BC137908 CH466575
GenPept AAI32148 AAI37909 BAA78343 BAE21654 BAE36432 CAI25323 EDL33558

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca