InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ADRB3

Summary

InnateDB Protein

IDBP-17241.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB3

Protein Name

adrenergic, beta-3-, receptor

Synonyms

BETA3AR;

Species

Homo sapiens

Ensembl Protein

ENSP00000343782

InnateDB Gene

IDBG-17239 (ADRB3)

Protein Structure

UniProt Annotation

Function

Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed mainly in adipose tissues.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	3 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004939	beta-adrenergic receptor activity
GO:0005515	protein binding
GO:0015052	beta3-adrenergic receptor activity
GO:0031699	beta-3 adrenergic receptor binding
GO:0042803	protein homodimerization activity
GO:0051379	epinephrine binding
GO:0051380	norepinephrine binding

Biological Process

GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0005975	carbohydrate metabolic process
GO:0006091	generation of precursor metabolites and energy
GO:0006112	energy reserve metabolic process
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0007568	aging
GO:0009409	response to cold
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042755	eating behavior
GO:0043410	positive regulation of MAPK cascade
GO:0046677	response to antibiotic
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000681 Beta 3 adrenoceptor
IPR002232 5-Hydroxytryptamine 6 receptor
IPR002233 Adrenoceptor family
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00563
PR01102
PR01103

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P13945