Version 5.4
Mus musculus Protein: Sbno2
Summary
InnateDB Protein IDBP-172507.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sbno2
Protein Name strawberry notch homolog 2 (Drosophila)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041635
InnateDB Gene IDBG-172505 (Sbno2)
Protein Structure
UniProt Annotation
Function Seems to have transcriptional repression activity in macrophages. {ECO:0000269PubMed:18025162}.
Subcellular Localization
Disease Associations
Tissue Specificity Detected in macrophages. IL10 regulates expression in a STAT3-dependent way. {ECO:0000269PubMed:18025162}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
Biological Process
GO:0002281 macrophage activation involved in immune response
GO:0006351 transcription, DNA-templated
GO:0030282 bone mineralization
GO:0030316 osteoclast differentiation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0050727 regulation of inflammatory response
GO:0061430 bone trabecula morphogenesis
GO:0072674 multinuclear osteoclast differentiation
GO:0072675 osteoclast fusion
Cellular Component
GO:0005575 cellular_component
Protein Structure and Domains
PDB ID MGI:2448490
InterPro IPR006935 Helicase/UvrB domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF04851
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7TNB8
PhosphoSite PhosphoSite-Q7TNB8
TrEMBL
UniProt Splice Variant
Entrez Gene 216161
UniGene Mm.262102
RefSeq NP_906271
MGI ID
MGI Symbol Sbno2
OMIM
CCDS CCDS24008
HPRD
IMGT
EMBL AJ512611 AK149806 AK155674 BC056369 BC064113
GenPept AAH56369 AAH64113 BAE29097 BAE33382 CAD54758

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca