Version 5.4
Mus musculus Protein: Papd4
Summary
InnateDB Protein IDBP-172571.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Papd4
Protein Name PAP associated domain containing 4
Synonyms 8030446C20Rik; AI649009; GLD-2; Gld2;
Species Mus musculus
Ensembl Protein ENSMUSP00000048124
InnateDB Gene IDBG-172569 (Papd4)
Protein Structure
UniProt Annotation
Function Cytoplasmic poly(A) RNA polymerase that adds successive AMP monomers to the 3'-end of specific RNAs, forming a poly(A) tail. In contrast to the canonical nuclear poly(A) RNA polymerase, it only adds poly(A) to selected cytoplasmic mRNAs. Does not play a role in replication-dependent histone mRNA degradation (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16325797}. Nucleus {ECO:0000269PubMed:16325797}.
Disease Associations
Tissue Specificity Ubiquitous. In brain, it is highly expressed in the cerebral cortex, cerebellum, hippocampus and olfactory bulb. {ECO:0000269PubMed:15987818, ECO:0000269PubMed:16325797}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004652 polynucleotide adenylyltransferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0006397 mRNA processing
GO:0043631 RNA polyadenylation
GO:0071044 histone mRNA catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2140950
InterPro IPR002058 PAP/25A-associated
PFAM PF03828
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91YI6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 100715
UniGene
RefSeq NP_598666
MGI ID
MGI Symbol Papd4
OMIM
CCDS CCDS26686
HPRD
IMGT
EMBL AK033141 AM419011 BC016629
GenPept AAH16629 BAC28170 CAL91354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca