InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Srd5a3

Summary

InnateDB Protein

IDBP-172752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Srd5a3

Protein Name

steroid 5 alpha-reductase 3

Synonyms

1110025P14Rik; A430076C09; AV364670; AW987574; D730040M03Rik; H5ar; S5AR 3; Srd5a2l;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031143

InnateDB Gene

IDBG-172750 (Srd5a3)

Protein Structure

UniProt Annotation

Function

Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT). {ECO:0000269PubMed:20637498}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity
GO:0016627	oxidoreductase activity, acting on the CH-CH group of donors
GO:0016628	oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
GO:0047751	cholestenone 5-alpha-reductase activity

Biological Process

GO:0006486	protein glycosylation
GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0006629	lipid metabolic process
GO:0016095	polyprenol catabolic process
GO:0019348	dolichol metabolic process
GO:0055114	oxidation-reduction process