InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hexa

Summary

InnateDB Protein

IDBP-172772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hexa

Protein Name

hexosaminidase A

Synonyms

Hex-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026262

InnateDB Gene

IDBG-172770 (Hexa)

Protein Structure

UniProt Annotation

Function

Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines, in the brain and other tissues.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Ubiquitous. Most abundant in testis, adrenal, epididymis and heart. Low levels seen in the liver. {ECO:0000269PubMed:7896264}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004563	beta-N-acetylhexosaminidase activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0005975	carbohydrate metabolic process
GO:0006689	ganglioside catabolic process
GO:0007040	lysosome organization
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0019915	lipid storage
GO:0019953	sexual reproduction
GO:0030203	glycosaminoglycan metabolic process
GO:0042552	myelination
GO:0048667	cell morphogenesis involved in neuron differentiation
GO:0050884	neuromuscular process controlling posture
GO:0050885	neuromuscular process controlling balance

Cellular Component

GO:0005764	lysosome
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:96073

InterPro

IPR015882 Beta-hexosaminidase, bacteial type, N-terminal
IPR015883 Glycoside hydrolase family 20, catalytic core
IPR017853 Glycoside hydrolase, superfamily
IPR025705 Beta-hexosaminidase
IPR029018 Chitobiase/beta-hexosaminidase domain 2-like

PFAM

PF02838
PF00728

PRINTS

PR00738

PIRSF

PIRSF001093

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt