InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gpx7

Summary

InnateDB Protein

IDBP-172778.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gpx7

Protein Name

glutathione peroxidase 7

Synonyms

3110050F08Rik; AI327032; GPX6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030332

InnateDB Gene

IDBG-172776 (Gpx7)

Protein Structure

UniProt Annotation

Function

It protects esophageal epithelia from hydrogen peroxide- induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0004602	glutathione peroxidase activity
GO:0016209	antioxidant activity
GO:0016491	oxidoreductase activity

Biological Process

GO:0006979	response to oxidative stress
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:1914555

InterPro

IPR000866 Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant
IPR000889 Glutathione peroxidase
IPR012336 Thioredoxin-like fold
IPR013376 Glutathione peroxidase Gpx7, putative

PFAM

PF00578
PF00255
PF13098
PF13192
PF13462
PF13905

PRINTS

PR01011

PIRSF

PIRSF000303

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt