InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxl15

Summary

InnateDB Protein

IDBP-172792.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl15

Protein Name

F-box and leucine-rich repeat protein 15

Synonyms

0710008C12Rik; Fbxo37;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000026256

InnateDB Gene

IDBG-172790 (Fbxl15)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, liver, spleen, bone, muscle, brain and kidney (at protein level). {ECO:0000269PubMed:21572392}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0009953	dorsal/ventral pattern formation
GO:0016567	protein ubiquitination
GO:0030282	bone mineralization
GO:0030513	positive regulation of BMP signaling pathway
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process