InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Jmy

Summary

InnateDB Protein

IDBP-172835.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Jmy

Protein Name

junction-mediating and regulatory protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070339

InnateDB Gene

IDBG-172833 (Jmy)

Protein Structure

UniProt Annotation

Function

Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location. {ECO:0000269PubMed:10518217, ECO:0000269PubMed:11511361, ECO:0000269PubMed:19287377, ECO:0000269PubMed:19897726}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:19287377, ECO:0000269PubMed:19897726}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Localizes to the nucleus in most cell types. In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells (By similarity). Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed, except in testis where it is expressed at low level. {ECO:0000269PubMed:10518217}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003713	transcription coactivator activity
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006281	DNA repair
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0007050	cell cycle arrest
GO:0034314	Arp2/3 complex-mediated actin nucleation
GO:0043065	positive regulation of apoptotic process
GO:0043620	regulation of DNA-dependent transcription in response to stress
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0070060	'de novo' actin filament nucleation
GO:0070358	actin polymerization-dependent cell motility
GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator