InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prok2

Summary

InnateDB Protein

IDBP-172889.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prok2

Protein Name

prokineticin 2

Synonyms

Bv8; PK2; Prok1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000032152

InnateDB Gene

IDBG-172887 (Prok2)

Protein Structure

UniProt Annotation

Function

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Expressed in the SCN and among a few other discrete brain areas, including the islands of Calleja, media l preoptic area of the hypothalamus and the shell of the nucleus accumbens. Highly expressed in testis. In the SCN, expression subjected to high amplitude of circadian oscillation.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001664	G-protein coupled receptor binding

Biological Process

GO:0001525	angiogenesis
GO:0003349	epicardium-derived cardiac endothelial cell differentiation
GO:0006935	chemotaxis
GO:0007218	neuropeptide signaling pathway
GO:0007283	spermatogenesis
GO:0007623	circadian rhythm
GO:0008283	cell proliferation
GO:0043066	negative regulation of apoptotic process
GO:0045987	positive regulation of smooth muscle contraction
GO:0060976	coronary vasculature development
GO:0060979	vasculogenesis involved in coronary vascular morphogenesis
GO:0060983	epicardium-derived cardiac vascular smooth muscle cell differentiation