Version 5.4
Mus musculus Protein: Bhmt
Summary
InnateDB Protein IDBP-172951.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bhmt
Protein Name betaine-homocysteine methyltransferase
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000096912
InnateDB Gene IDBG-172949 (Bhmt)
Protein Structure
UniProt Annotation
Function Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0047150 betaine-homocysteine S-methyltransferase activity
Biological Process
GO:0006579 amino-acid betaine catabolic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation
Cellular Component
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1339972
InterPro IPR003726 Homocysteine S-methyltransferase
IPR017226 Betaine-homocysteine S-methyltransferase, BHMT
PFAM PF02574
PRINTS
PIRSF PIRSF037505
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O35490
PhosphoSite PhosphoSite-O35490
TrEMBL
UniProt Splice Variant
Entrez Gene 12116
UniGene Mm.423099
RefSeq NP_057877
MGI ID
MGI Symbol Bhmt
OMIM
CCDS CCDS36748
HPRD
IMGT
EMBL AF033381 AH009623 AK145668 AK149457 AK166754 AK166818 BC037004 BC093510 BC110307
GenPept AAB87501 AAF85944 AAH37004 AAH93510 AAI10308 BAE26578 BAE28890 BAE38995 BAE39044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca