InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rybp

Summary

InnateDB Protein

IDBP-172990.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rybp

Protein Name

RING1 and YY1 binding protein

Synonyms

2410018J24Rik; DEDAF; YEAF1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098677

InnateDB Gene

IDBG-172988 (Rybp)

Protein Structure

UniProt Annotation

Function

Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17070805}. Cytoplasm {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000269PubMed:17070805}. Note=Primarily found in the nucleus. Detected in a punctate pattern likely to represent Polycomb group (PcG) bodies.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	27 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006915	apoptotic process
GO:0035518	histone H2A monoubiquitination