InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Shq1

Summary

InnateDB Protein

IDBP-173009.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Shq1

Protein Name

SHQ1 homolog (S. cerevisiae)

Synonyms

2810403P18Rik; Grim-1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000086656

InnateDB Gene

IDBG-173007 (Shq1)

Protein Structure

UniProt Annotation

Function

Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Nucleus, nucleoplasm {ECO:0000250}. Note=May at least partially shuttle between cytosol and nucleoplasm. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0022618	ribonucleoprotein complex assembly
GO:0043065	positive regulation of apoptotic process
GO:2000233	negative regulation of rRNA processing

Cellular Component

GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1919421

InterPro

IPR007009 SHQ1 protein
IPR007052 CS domain
IPR008978 HSP20-like chaperone

PFAM

PF04925
PF04969

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TMX5

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

72171

UniGene

Mm.256022

RefSeq

XP_006506732

MGI ID

MGI Symbol

Shq1

OMIM

CCDS

HPRD

IMGT

EMBL

AK012978 BC052657

GenPept

AAH52657